Conditions We Treat
Histamine Intolerance / MCAS
Histamine intolerance isn't a true allergy, it's a capacity problem. Your body produces histamine, your gut bacteria produce histamine, and the foods you eat contain histamine. When production exceeds your ability to break it down, symptoms appear everywhere.
Common Symptoms
Does this sound like you? These symptoms may seem unrelated, but they share common root signals.
The Signal-Based Medicine Perspective
Root Causes of Histamine Intolerance / MCAS
Your body clears histamine through two enzymes: DAO (in the gut) and HNMT (intracellularly). When DAO is impaired, by gut inflammation, nutrient deficiencies, medications, or genetics, histamine from food and bacteria accumulates. Simultaneously, if your gut microbiome is overpopulated with histamine-producing bacteria, you're creating more histamine than you can clear. The result looks like allergies but isn't.
- DAO enzyme deficiency or dysfunction
- Gut bacteria overproducing histamine
- Intestinal permeability
- HNMT genetic variants
- Mast cell activation
- Medications blocking DAO (NSAIDs, antidepressants)
Advanced Diagnostics
How Kure Health Tests for Histamine Intolerance / MCAS
Treatment
What Drives Histamine Intolerance / MCAS?
We identify whether histamine intolerance stems from DAO deficiency, gut dysbiosis, mast cell activation, or a combination, then address each pathway: restore DAO function, rebalance gut bacteria, repair intestinal barrier, and calm mast cell reactivity.
Frequently Asked Questions
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